*All children must be accompanied by an adult   Tuesday-Saturday   10:00AM-5:00PM You are invited to become a member of the Historic DeSoto Foundation.  Click here to find out more.                             Below are directions to the DeSoto County Museum.  We hope you will visit us soon. From Memphis: South out of Memphis on I-55, continue to the Hernando exit # 280 Turn right at the off ramp, then go west on Commerce St. You will cross over railroad tracks. The museum will be on your left approximately 200 yards ahead.